Statistical Genetics
BS858: Genetics, inheritance, complex traits, and testing for gene components
Genetics and Inheritance
Gregor Mendel was an Austrian Monk in the late 1800s who experimented with pea plants to find tra...
Linkage Analysis
The primary goal of linkage analysis is to determine the location (chromosome and region) of gene...
Assessing the Genetic Component of a Phenotype
A phenotype is the appearance of an individual, which results from the interaction of the person'...
Population Genetics
Genotype and Allele Frequency Estimation is the first step in studying a polymorphism. Used for f...
Association Testing in Unrelated Individuals
In association testing we are interested in the effect of a specific allele in the population. We...
Multiple Comparisons and Evaluating Significance
In 1978 Restricted Fragment Linked Polymorphisms (RFLPSs) were used for linkage analysis. In 1...
Association Testing in Related Individuals
Family data is correlated that could lead to inflation in test statistics if not accounted for. M...
Haplotypes and Imputation
When multiple markers/SNPs are genotyped in a gene or gene region, the SNPs may be in linkage dis...
Power and Sample Size Calculations for Association Studies
Review of errors and difference in means/proportions:Type II error is represented by beta and typ...
Sequencing Data and Analysis of Rare Variants
Genotyping arrays can be obtained at pre-selected sites for each sample. Ex. Genotyping sites kno...
Interactions in Genetic Assocation Analysis
Statistical interaction occurs between two factors if their combined effect is different than wha...
Meta Analysis
GWAS is performed on millions of SNPs. Because of multiple testing, we use very stringent thresho...